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Patterns of expression of MMR proteins in serrated adenomas and other polyps of the colorectum
  1. H Bonte,
  2. J-F Fléjou
  1. Service d’Anatomie Pathologique, hôpital Saint-Antoine, AP-HP, Paris, France
  1. Correspondence to:
    Professor J-F Fléjou, Service d’Anatomie Pathologique, Hôpital Saint- Antoine-AP-HP, 184, rue du Faubourg Saint-Antoine, 75571, Paris cedex 12, France;
    jean-francois.flejou{at}sat.ap-hop-paris.fr

https://doi.org/10.1136/gut.52.4.611

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    We read with a great interest the study by Sawyer et al (Gut 2002;51:200–6). This well performed study of numerous genetic and immunohistochemical features of serrated adenomas (SAs) of the colorectum furnishes very important findings that may help to clarify the confusing field of colorectal tumorigenesis. Using both molecular and immunohistochemical techniques, Sawyer et al found in a series of 39 SAs a relatively low frequency of most abnormalities described in classical adenomas and adenocarcinomas of the colorectum. Comparative genomic hybridisation, performed in four cases, was always normal. These differences from classical adenomas may be due either to a distinct mechanism of tumorigenesis or to the presence of a large number of SAs showing only mild (64%) or moderate (28%) dysplasia. An interesting result obtained by Sawyer et al is the absence of high level microsatellite instability (MSI-H) in SAs, and the rarity of low level microsatellite instability (MSI-L) …

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