Recent experimental studies may undermine our understanding of the gastrointestinal side effects of non-steroidal anti-inflammatory drugs and cast a shadow on the original concept that underpins the development of the recent addition to the clinical anti-inflammatory armamentarium, the COX-2 selective inhibitors. But is this just a passing cloud or a total eclipse of the COX theory?
- cyclooxygenase 1
- cyclooxygenase 2
- non-steroidal anti-inflammatory drugs
- gastric injury
- NSAIDs, non-steroidal anti-inflammatory drugs
- NO, nitric oxide
- iNOS, inducible nitric oxide synthase
- AS, ankylosing spondylitis
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