Article Text

Download PDFPDF

A rare cause of gastrointestinal bleeding in a patient with hyper-IgE syndrome
  1. M Götzberger1,
  2. A Schlesinger1,
  3. M Dauer1,
  4. W Heldwein1,
  5. A Jansson2,
  6. E Renner2,
  7. B H Belohradsky2
  1. 1Medizinische Klinik-Innenstadt, Klinikum der Universität München, München, Germany
  2. 2Haunersche Kinderklinik, Klinikum der Universität München, München, Germany
  1. Correspondence to:
    Dr M Götzberger
    Klinikum der Universität München, Medizinische Klinik-Innenstadt, Ziemssenstr 1, D-80336 München, Germany;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Clinical presentation

A 36 year old man was referred to our hospital with signs of gastrointestinal bleeding. He presented with melaena, paleness of the skin, and general weakness, worsening over the last three weeks. Vomiting was absent. The patient has been known to suffer from hyper-IgE syndrome, a primary immunodeficiency disease causing recurrent bacterial infections. During the history of the present illness, the patient described intermittent stool irregularities with dark to black colour without fresh blood for six month as well as painful bowel movements.

Laboratory values were significant for severe anaemia (haemoglobin 5.0 g/dl) and mild elevation of parameters reflecting inflammation (white blood cell count 13 900/µl, C reactive protein 2.8 mg/dl).

The patient underwent gastroscopic examination showing flat healing defects of 4–12 mm in the whole circumference of the descending duodenum as well as thickened folds in this area. The lesions did not present with any signs of bleeding. Therefore, colonoscopy was performed the following day.


What conclusions would you draw from these colonoscopy findings (fig 1)?
See page 1436for answer

Figure 1

 Endoscopic view of the colon.

This case is submitted by:


  • Robin Spiller, Editor

Linked Articles

  • Miscellaneous
    BMJ Publishing Group Ltd and British Society of Gastroenterology