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Studies of acid exposure immediately above the gastro-oesophageal squamocolumnar junction: evidence of short segment reflux
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  • Published on:
    Effect of Midazolam and Endoscopy on Lower Esophageal Sphincter (LES) Function.

    Dear Editors

    With interest we read the article by J Fletcher et al,[1] entitled "Studies of acid exposure immediately above the gastroesophageal squamocolumnar junction: evidence of short segment reflux" published in the recent issue of GUT. Demonstration of an increased acid exposure to the most distal esophagus vs. 5 cm above the lower esophageal importantly contributes to better understanding of the...

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    Conflict of Interest:
    None declared.
  • Published on:
    Authors' Reply to Nandurkar: Short segment reflux and acid pocket

    Dear Editor

    We thank Dr Nandurkar for his interest[1] in our recent papers regarding luminal acidity at the gastro-oesophageal junction following meals.

    In our first study, we observed a postprandial region of high acidity in the cardia region and extending across the Z-line.[2] The presence of this postprandial acid pocket at the cardia has been confirmed by two other groups[3,4]

    In our more rec...

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    Conflict of Interest:
    None declared.
  • Published on:
    Short segment reflux: Acid but no Pocket?

    Dear Editor

    I read the recent paper by Fletcher et al. with interest.[1]

    In your earlier study,[2] your group reported the existence of an unbuffered acid pocket in 60% of your study subjects which extended for approximately 2 cms (median length) in the postprandial period. Furthermore, when pre and post-prandial pH step up distances were measured and correlated with clips fixed to the oesophagus...

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    Conflict of Interest:
    None declared.