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Sporadic duodenal adenoma is associated with colorectal neoplasia
  1. M A Murray1,
  2. M J Zimmerman2,
  3. H C Ee1
  1. 1Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Western Australia, Australia
  2. 2Department of Gastroenterology, Royal Perth Hospital, Western Australia, Australia
  1. Correspondence to:
    Dr H C Ee
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia;


Objective: The objective of this study was to assess the association between colorectal neoplasia and sporadic duodenal adenoma.

Methods: A retrospective case control study was conducted using the databases of two major teaching hospitals in Western Australia. The frequency of colorectal neoplasia in patients with sporadic duodenal adenomas was compared with that in a control group of patients presenting for endoscopies. The frequency of colorectal cancer in duodenal adenoma patients was also compared with the population incidence.

Results: Of 56 sporadic duodenal adenoma patients, 34 (61%) had been colonoscoped. When comparing the findings between patients with sporadic duodenal adenoma and an endoscoped control group, all colorectal neoplasias were significantly more common in the duodenal adenoma group (56% v 33%; odds ratio (OR) 2.4 (95% confidence intervals (CI) 1.1–5.4)). Although finding either advanced colorectal adenoma or cancer was also more common in duodenal adenoma patients (38% v 19%; OR 2.3 (95% CI 1.0–5.2)), as was finding colorectal cancer alone (21% v 8%; OR 3.0 (95% CI 1.0–9.1)), the results were not statistically significant. However, the incidence of colorectal cancer was much greater in duodenal adenoma patients than in the population (p<0.001).

Conclusions: Sporadic duodenal adenoma has a clinically important association with colorectal neoplasia. Thus patients with duodenal adenomas should undergo colonoscopy to detect colorectal neoplasia.

  • duodenal adenoma
  • colorectal neoplasia
  • colorectal cancer
  • colonoscopy
  • CI, confidence intervals
  • FAP, familial adenomatous polyposis
  • HNPCC, hereditary non-polyposis colorectal cancer
  • OR, odds ratio

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