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Duodenal adenomatosis in familial adenomatous polyposis
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  • Published on:
    Authors reply to Drs. Latchford and Phillips
    • Steffen Bülow, Consultant surgeon
    • Other Contributors:
      • Jan Björk, Ib J. Christensen, Olav Fausa, Heikki Järvinen, Flemming Moesgaard, and Hans F.A. Vasen

    Dear Editor

    This letter is in response to the letter by Latchford and Phillips.[1]

    We agree that the ideal upper endoscopy for evaluation of duodenal adenomatosis in FAP should be performed with a side viewing as well as a forward viewing endoscope, but as pointed out by Latchford & Phillips we underlined and discussed this problem in our article.[2] Our Nordic- Dutch study was planned in the late 1...

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    Conflict of Interest:
    None declared.
  • Published on:
    Duodenal adenoma and cancer in FAP

    Dear Editor

    We congratulate the authors on gathering this large cohort of patients in this important area in FAP but would like to express some reservations with regards the study. Our first concern relates to the means of endoscopic assessment. Standard forward viewing endoscopy was used, whereas in clinical practice side viewing endoscopy is recommended since duodenal polyposis in FAP is more severe in the peria...

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    Conflict of Interest:
    None declared.
  • Published on:
    Authors reply to Dr Biasco et al.

    Dear Editor

    This letter is in response to the letter by Biasco et al.[1]

    In our study [2] of 368 patients with a median follow-up of 91 months the cumulative incidence of duodenal adenomatosis Spigelman stage IV was 52% at age 70, which is in fact almost the same life time risk as the 50% found by Saurin et al.[3] and 20-30% in the Swedish and Finnish series.[4,5]

    In conclusion, all major...

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    Conflict of Interest:
    None declared.
  • Published on:
    The risk of duodenal cancer in patients with Familial Adenomatous Polyposis
    • Guido Biasco, Professor
    • Other Contributors:
      • Maria A. Pantaleo, Giulio Di Febo, Carlo Calabrese and Giovanni Brandi

    Dear Editor

    Bülow and coworkers published the results of a prospective multicenter study addressed to the analysis of the natural history of duodenal adenomas in Familial Adenomatous Polyposis (FAP).[1]

    368 patients were examined in a mean period of 7.6 years (range 0.5-10.4). They show a significative progression of Spigelman stage over time (p< 0.0001). At the end of the study the incidence of Spigel...

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    Conflict of Interest:
    None declared.