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Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study
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  • Published on:
    Response to M Guido and M Rugge

    Dear Editor

    Mario Guido and Massimo Rugge make important points about the interpretation of liver biopsy if the sample is small.[1]

    Our study [2] was accepted for publication before the Colloredo article was published in the Journal of Hepatology and we would agree that the standards for accepting a liver biopsy as adequate have changed in the light of their data.

    With respect to our study,...

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    Conflict of Interest:
    None declared.
  • Published on:
    Liver fibrosis: natural history may be affected by the biopsy sample

    Dear Editor

    We read with great interest the article by Ryder and the Trent hepatitis C Study Group,[1] addressing the issue of fibrosis progression in untreated patients with chronic hepatitis C. After examining a large series of paired liver biopsies (median inter-biopsy interval: 2.5 years), the Authors conclude that, even in patients with a "histologically mild" presentation, chronic hepatitis C is characterized...

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    Conflict of Interest:
    None declared.