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Letter
Adoptive transfer of genetic susceptibility to Crohn’s disease
  1. C Folwaczny,
  2. J Glas,
  3. T Mussack,
  4. H P Török
  1. Klinikum Innenstadt, Ludwig-Maximilians University, Munich, Germany
  1. Correspondence to:
    Dr C Folwaczny;
    Christian.Folwacznymedinn.med.uni-muenchen.de

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    We read with interest the stimulating case report on fulminant Crohn’s colitis following allogenic stem cell transplantation by

    Sonwalkar et al (Gut2003;52:1518–21)
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    and the respective editorial.1 The authors and the editorialists hypothesised on whether the colitis might be ascribed to the adoptive transfer of stem cells displaying genetic alterations which are associated with Crohn’s disease. However, the ileal sparing disease localisation and course of the colitis which finally necessitated urgent colectomy is rather unusual for Crohn’s colitis. In addition, the genetic mismatch between donor and recipient is hardly compatible …

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