Article Text
Leading article
Fatigue in chronic cholestasis
Abstract
Fatigue is probably the most intriguing symptom affecting patients with chronic cholestatic disorders, in particular those with primary biliary cirrhosis. It is postulated that fatigue in patients with primary biliary cirrhosis may be associated with morphological abnormalities of the central nervous system secondary to accumulation of manganese. However, we are still far from understanding this complex issue.
- fatigue
- cholestasis
- primary biliary cirrhosis
- magnetisation transfer ratio
- manganese
- SLE, systemic lupus erythematosus
- PBC, primary biliary cirrhosis
- Mn, manganese
- 1H MRS, proton magnetic resonance spectroscopy
- MTR, magnetisation transfer ratio
- PSE, portosystemic encephalopathy
- CNS, central nervous system
- GP, globus pallidus