You are here

Article Text

Article menu
Download PDFPDF
Letter
Cross reactivity due to positive canrenone interference
  1. R G Romanelli,
  2. P Gentilini
  1. Università degli Studi di Firenze, Dipartimento di Medicina Interna, Viale Morgagni, 85 50134 Florence, Italy
  1. Correspondence to:
    Dr R G Romanelli;
    r.romanellidmi.unifi.it

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Canrenone is a selective competitive inhibitor of the aldosterone receptor and a diuretic drug commonly used in the treatment of cirrhotic patients both with and without ascites.1 The aim of our observation was to determine if canrenone cross reacts with aldosterone in an immunoradiosorbent assay kit used for the hormonal scoring system according to the Child-Pugh classification for liver cirrhosis.2 Canrenone, for in vitro experiments, was a gift from GiEnne Pharma (Group Therabel) Diagnostics. Canrenone, potassium canrenoate, and spironolactone are often used with digoxin in clinical practice and can cause falsely low readings in common assays for digoxin (that is, AxSym MEIA-Abbott) due to negative cross reactivity, and …

    View Full Text