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Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
  1. R C Fitzgerald,
  2. C Caldas
  1. Hutchison/MRC Research Centre, Cambridge, UK
  1. Correspondence to:
    Dr R Fitzgerald
    Hutchison/MRC Research Centre, Hills Rd, Cambridge CB2 2XZ, UK;


Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).

  • E-cadherin
  • gastric cancer
  • gastrectomy
  • genetic susceptibility
  • screening
  • HDGC, hereditary diffuse gastric cancer

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