You are here

Article Text

Article menu
Download PDFPDF
Leading article
Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
  1. R C Fitzgerald,
  2. C Caldas
  1. Hutchison/MRC Research Centre, Cambridge, UK
  1. Correspondence to:
    Dr R Fitzgerald
    Hutchison/MRC Research Centre, Hills Rd, Cambridge CB2 2XZ, UK; rcfhutchison-mrc.cam.ac.uk

Abstract

Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).

  • E-cadherin
  • gastric cancer
  • gastrectomy
  • genetic susceptibility
  • screening
  • HDGC, hereditary diffuse gastric cancer

https://doi.org/10.1136/gut.2003.022061

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    Linked Articles