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H pylori infection and reflux oesophagitis
  1. J Kountouras,
  2. C Zavos,
  3. D Chatzopoulos
  1. Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece
  1. Correspondence to:
    Dr J Kountouras
    8 Fanariou St, Byzantio, 551 33, Thessaloniki, Macedonia, Greece;

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We read with considerable interest the paper by Kuipers et al (Gut 2004;53:12–20) which found no significant adverse impact on the severity of reflux disease or its control after two years of omeprazole therapy following H pylori eradication, during which time gastritis largely healed. In the commentary by McColl (Gut 2004;53:5–7), it is stated that although published data are conflicting, Schwizer et al reported improvement in reflux symptoms following H pylori treatment.1 Our preliminary published data,2 which are in accordance with those of Schwizer and colleagues,1 consisted of a small cohort of 69 patients with gastro-oesophageal reflux disease (GORD) and irritable bowel syndrome (IBS). Forty patients were treated with omeprazole (20 mg/day) plus trimebutine (600 mg/day) for three months (group A) and 29 were treated with omeprazole (20 mg/day) as monotherapy …

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