Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis

D Franchimont; S Vermeire; H El Housni; M Pierik; K Van Steen; T Gustot; E Quertinmont; M Abramowicz; A Van Gossum; J Devière; P Rutgeerts

doi:10.1136/gut.2003.030205

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Inflammatory bowel disease

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis

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	Abstract	Full	Pdf
Jun 2004	210	486	263
Jul 2004	147	430	147
Aug 2004	116	355	146
Sep 2004	104	214	77
Oct 2004	53	184	85
Nov 2004	90	188	82
Dec 2004	27	119	57
Jan 2005	44	107	65
Feb 2005	57	135	79
Mar 2005	43	116	62
Apr 2005	36	89	57
May 2005	24	85	37
Jun 2005	34	75	40
Jul 2005	22	78	70
Aug 2005	26	109	91
Sep 2005	34	100	74
Oct 2005	31	106	75
Nov 2005	28	102	60
Dec 2005	17	63	55
Jan 2006	18	95	41
Feb 2006	21	92	62
Mar 2006	15	66	49
Apr 2006	21	91	60
May 2006	29	35	31
Jun 2006	13	32	25
Jul 2006	14	45	36
Aug 2006	18	51	44
Sep 2006	18	60	48
Oct 2006	38	70	47
Nov 2006	20	64	43
Dec 2006	18	56	36
Jan 2007	44	63	67
Feb 2007	22	39	42
Mar 2007	40	62	38
Apr 2007	43	37	37
May 2007	30	16	13
Jun 2007	31	21	25
Jul 2007	22	18	20
Aug 2007	27	22	21
Sep 2007	24	26	25
Oct 2007	39	18	24
Nov 2007	27	16	16
Dec 2007	25	22	18
Jan 2008	32	30	28
Feb 2008	29	19	15
Mar 2008	22	11	8
Apr 2008	33	24	18
May 2008	41	11	13
Jun 2008	27	12	11
Jul 2008	31	8	10
Aug 2008	42	9	7
Sep 2008	28	8	8
Oct 2008	39	7	10
Nov 2008	36	9	15
Dec 2008	18	5	12
Jan 2009	34	5	12
Feb 2009	37	8	15
Mar 2009	39	7	6
Apr 2009	41	6	10
May 2009	46	10	18
Jun 2009	25	2	4
Jul 2009	51	9	10
Aug 2009	36	8	10
Sep 2009	28	3	4
Oct 2009	58	8	7
Nov 2009	46	3	10
Dec 2009	52	8	13
Jan 2010	44	8	9
Feb 2010	34	3	10
Mar 2010	60	10	16
Apr 2010	36	7	11
May 2010	36	5	12
Jun 2010	23	2	5
Jul 2010	32	10	10
Aug 2010	32	9	15
Sep 2010	42	6	9
Oct 2010	49	16	10
Nov 2010	43	12	4
Dec 2010	32	12	9
Jan 2011	36	2	6
Feb 2011	29	7	7
Mar 2011	59	12	11
Apr 2011	52	2	8
May 2011	41	9	6
Jun 2011	25	3	5
Jul 2011	31	1	7
Aug 2011	21	4	8
Sep 2011	34	6	6
Oct 2011	61	3	7
Nov 2011	39	10	19
Dec 2011	49	9	15
Jan 2012	41	21	28
Feb 2012	47	13	14
Mar 2012	51	16	22
Apr 2012	32	12	14
May 2012	44	30	16
Jun 2012	45	12	13
Jul 2012	44	17	11
Aug 2012	24	23	15
Sep 2012	43	8	21
Oct 2012	39	18	17
Nov 2012	52	18	16
Dec 2012	56	19	14
Jan 2013	62	37	15
Feb 2013	44	29	10
Mar 2013	50	22	79
Apr 2013	62	20	21
May 2013	49	29	24
Jun 2013	46	11	12
Jul 2013	35	11	11
Aug 2013	56	21	9
Sep 2013	55	18	17
Oct 2013	53	16	12
Nov 2013	55	17	17
Dec 2013	50	12	15
Jan 2014	67	14	13
Feb 2014	45	15	13
Mar 2014	87	32	16
Apr 2014	45	18	12
May 2014	57	21	6
Jun 2014	53	8	13
Jul 2014	65	24	19
Aug 2014	38	19	13
Sep 2014	60	17	14
Oct 2014	49	20	7
Nov 2014	74	16	13
Dec 2014	52	19	15
Jan 2015	47	17	5
Feb 2015	60	16	13
Mar 2015	70	26	8
Apr 2015	79	11	4
May 2015	79	6	9
Jun 2015	67	5	5
Jul 2015	46	7	5
Aug 2015	52	7	4
Sep 2015	104	12	6
Oct 2015	53	12	7
Nov 2015	70	10	6
Dec 2015	94	6	9
Jan 2016	71	8	4
Feb 2016	49	17	7
Mar 2016	30	7	8
Apr 2016	38	24	14
May 2016	18	13	7
Jun 2016	45	13	8
Jul 2016	35	7	7
Aug 2016	33	8	7
Sep 2016	53	9	8
Oct 2016	49	10	5
Nov 2016	77	5	12
Dec 2016	56	8	3
Jan 2017	71	7	12
Feb 2017	35	6	9
Mar 2017	31	20	15
Apr 2017	35	24	13
May 2017	17	36	15
Jun 2017	15	30	6
Jul 2017	50	36	6
Aug 2017	46	34	8
Sep 2017	381	329	8
Oct 2017	392	336	15
Nov 2017	408	352	5
Dec 2017	1791	1667	28
Jan 2018	1811	1694	32
Feb 2018	757	675	20
Mar 2018	785	700	26
Apr 2018	769	700	21
May 2018	1140	1036	37
Jun 2018	424	360	18
Jul 2018	734	672	19
Aug 2018	1098	1020	20
Sep 2018	35	13	5
Oct 2018	284	224	19
Nov 2018	338	274	24
Dec 2018	72	48	10
Jan 2019	70	48	5
Feb 2019	53	35	16
Mar 2019	54	24	13
Apr 2019	28	16	17
May 2019	47	23	15
Jun 2019	28	12	24
Jul 2019	28	9	26
Aug 2019	33	21	21
Sep 2019	30	9	17
Oct 2019	25	12	14
Nov 2019	53	35	20
Dec 2019	44	15	5
Jan 2020	38	24	10
Feb 2020	45	33	6
Mar 2020	69	40	20
Apr 2020	37	25	13
May 2020	34	30	11
Jun 2020	64	52	12
Jul 2020	68	54	4
Aug 2020	66	48	19
Sep 2020	101	73	22
Oct 2020	61	46	13
Nov 2020	65	45	7
Dec 2020	44	29	30
Jan 2021	59	41	11
Feb 2021	55	46	21
Mar 2021	57	47	20
Apr 2021	43	28	20
May 2021	39	30	19
Jun 2021	36	36	19
Jul 2021	30	29	16
Aug 2021	15	15	18
Sep 2021	26	25	31
Oct 2021	32	26	26
Nov 2021	30	22	26
Dec 2021	52	27	10
Jan 2022	38	18	18
Feb 2022	32	25	10
Mar 2022	49	27	13
Apr 2022	56	25	20
May 2022	48	36	17
Jun 2022	38	30	14
Jul 2022	39	20	16
Aug 2022	50	32	12
Sep 2022	47	32	16
Oct 2022	45	35	12
Nov 2022	72	53	8
Dec 2022	70	59	5
Jan 2023	74	60	11
Feb 2023	94	73	8
Mar 2023	65	58	7
Apr 2023	22	12	14
May 2023	38	24	15
Jun 2023	34	23	11
Jul 2023	33	17	9
Aug 2023	34	18	7
Sep 2023	61	50	16
Oct 2023	50	46	16
Nov 2023	61	47	12
Dec 2023	139	6	0
Jan 2024	104	7	5
Feb 2024	112	4	2
Mar 2024	222	6	3
Total	21678	17859	5042

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