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Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis
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  • Published on:
    Reply to Franchimont et al
    • Servaas A Morré, Laboratory of Immunogenetics
    • Other Contributors:
      • Sander Ouburg, Rosalie Mallant-Hent, J. Bart A. Crusius, Ad A van Bodegraven, Chris J.J. Mulder, Ronald Linskens and A. Salvador Peña.
    Dear Editor

    It is with great interest that we read the paper by Franchimont et al[1] in which they describe a novel association of the Toll-like receptor 4 (TLR4) +896 A>G polymorphism with both Crohn’s disease (CD) and ulcerative colitis (UC), supporting the genetic influence of pattern recognition receptors (PRRs) in triggering inflammatory bowel disease (IBD). PRRs are sensors of pattern associated molecu...

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    Conflict of Interest:
    None declared.
  • Published on:
    Reply:
    • Denis Franchimont
    • Other Contributors:
      • Severine Vermeire, Jacques Deviere, and Paul Rutgeerts

    Dear Editor

    We would like to thank Doctor Ian Arnott for this very interesting comment.[1] Needless to say that we all agree that great caution should apply when reporting positive or negative association studies because of issues such as sample size, cryptic population substructure or phenotype misclassification. To this end, a TDT should always be performed to alleviate skepticism and doubts. It is true that a...

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    Conflict of Interest:
    None declared.
  • Published on:
    The toll like receptor-4 gene in IBD: further evidence for genetic heterogeneity in Europe
    • Ian DR Arnott, Consultant Gastroentereologist
    • Other Contributors:
      • Gwo-Tzer Ho, Elaine R Nimmo, Jack Satsangi

    Dear Editor

    There is now strong evidence implicating the enteric flora in aeitiopathogenesis of IBD and the identification of CARD15 (NOD2) as a pattern recognition receptor (PRR) has given novel insights in to host bacteria interactions. CARD15 is implicated as the intracellular sensor of muramyl dipeptide, a highly conserved bacterial peptidoglycan motif, and raises the question whether other PRRs are involved...

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    Conflict of Interest:
    None declared.