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Serum pro-hepcidin: measuring active hepcidin or a non-functional precursor?
  1. M J Brookes,
  2. N K Sharma,
  3. C Tselepis,
  4. T H Iqbal
  1. City Hospital, Birmingham, UK
  1. Correspondence to:
    Dr M J Brookes
    City Hospital, Dudley Rd, Birmingham B18 7QH, UK; mbro453398aol.com

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We read with great interest the paper “Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia” (Gut 2004;53:735–43) .

We have two observations. Firstly it was shown that pro-hepcidin and hepcidin were colocalised within the liver and in Hep-G cells. However, it was not possible, using serum ELISA, to identify the C terminus of …

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