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DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population
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  • Published on:
    Authors' reply to Browning
    • Jack Satsangi, Professor
    • Other Contributors:
      • Colin Noble, Ian D.R. Arnott, Richard K.R. Russell, Elaine R Nimmo

    Dear Editor,

    We note Dr Browning's interest in our work. Unfortunately, we find his letter to be factually incorrect, and therefore scientifically misleading.

    In attempting to analyse further our own data, he has made invalid assumptions regarding our data set, which render his calculations inaccurate, and his conclusions inappropriate. Moreover, the selected literature references which he quotes omit c...

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    Conflict of Interest:
    None declared.
  • Published on:
    DLG5 variants and susceptibility to inflammatory bowel disease in the Scottish population

    Dear Editor,

    The recent study by Noble and colleagues[1] did not find an association of the DLG5 G113A polymorphism with either inflammatory bowel disease (IBD) or Crohn’s disease (CD). Previous studies in other European populations had reported an increase in 113A allele frequency in IBD and CD patients [2,3], but, in striking contrast, Noble et al.[1] reported a trend toward decreased carrier frequency for the 1...

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    Conflict of Interest:
    None declared.