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Bacterial DNA induces a proinflammatory immune response in patients with decompensated cirrhosis
  1. J Such1,
  2. C Muñoz2,
  3. P Zapater3,
  4. M Pérez-Mateo4
  1. 1Liver Unit, Hospital General Universitario, Pintor Baeza s/n, Alicante, Spain
  2. 2Department of Immunology, Hospital General Universitario, Pintor Baeza s/n, Alicante, Spain
  3. 3Department of Clinical Pharmacology, Hospital General Universitario, Pintor Baeza s/n, Alicante, Spain
  4. 4Liver Unit, Hospital General Universitario, Pintor Baeza s/n, Alicante, Spain
  1. Correspondence to:
    Dr J Such
    Liver Unit, Hospital General Universitario, Pintor Baeza s/n, Alicante, Spain; such_josgva.es

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    We read with interest the study of Thalheimer et al (Gut 2005;54:556–63) in which they reviewed actual knowledge regarding the influence of infection on haemodynamics, variceal haemorrhage, heparinoid effects, liver damage, and other effects.

    We agree with these assumptions and would like to add information not quoted in the paper that may help explain some of the immune abnormalities usually found in patients with advanced decompensated cirrhosis. As the authors detailed in their paper, our group has reported on the detection of bacterial DNA in a significant proportion of patients with cirrhosis and culture negative non-neutrocytic ascites,1 and has also shown that these fragments may last in blood for variable …

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    • Conflict of interest: None declared.

    Footnotes

    • Conflict of interest: None declared.

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