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Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications
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  • Published on:
    Re: Do baseline ALT levels predict complications of chronic hepatitis B?

    Dear Editor We would like to thank Dr Huo and his colleagues for their comments. The followings are point-by-point responses to their comments.

    1) The serum ALT levels were not considered in our analysis of prognostic factors because the stratification into 5 groups rendered it too complicated for statistical calculation of multivariate analysis. In addition, we aimed to examine independently the differences...

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    Conflict of Interest:
    None declared.
  • Published on:
    Do baseline ALT levels predict complications of chronic hepatitis B?
    • Teh-Ia Huo, M.D.
    • Other Contributors:
      • Jaw-Ching Wu, Shou-Dong Lee

    Dear Editor,

    We read with interest the paper by Yuen et al. published in a recent issue of Gut.[1] This study included a large patient cohort with chronic hepatitis B and analyzed the determinants predicting the outcome. Authors concluded that low level viremia and mildly elevated serum ALT levels more commonly lead to the development of complications. This conclusion, however, is not supported by their findings...

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    Conflict of Interest:
    None declared.