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ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients
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  • Published on:
    Re: Is ITPA genotyping predictive for the development of side effects to AZA?
    • Jolanda M van Dieren, PhD student
    • Other Contributors:
      • Hanneke A.J. van Vuuren, Ernst J. Kuipers, Bettina E. Hansen, Johannes G. Kusters, Edward E.S. Nieuwenhuis, C. Janneke van der Woude

    Dear Editor,

    In response to the comments of Duley et al. to our letter published in GUT 2005 we would like to make some additional remarks.

    First of all, Duley et al. conclude that our study had a retrospective character, but this is not correct. This is a longitudinal cohort study in which all patients with IBD visiting our out-patient department were included. These patients were followed prospectively fo...

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    Conflict of Interest:
    None declared.
  • Published on:
    Is ITPA genotyping predictive for the development of side effects to AZA?
    • John A Duley, Senior Scientist
    • Other Contributors:
      • Anthony M. Marinaki, Monica Arenas, and Timothy H. J. Florin

    Dear Editor

    In a retrospective study of patients with inflammatory bowel disease, van Dieren et al recently reported the absence of correlation between genotypes for both inosine triphosphate pyrophosphatase (ITPA) thiopurine methyltransferase (TPMT) with any side effects to azathioprine (AZA) (Gut 2005;54:1664). This contrasts with two other studies. A rigorous prospective study recently published has demonstrat...

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    Conflict of Interest:
    None declared.