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PMS2 mutations in childhood cancer
  1. D T Bonthron,
  2. B E Hayward,
  3. M De Vos,
  4. E Sheridan
  1. University of Leeds, Leeds, UK
  1. Correspondence to:
    Professor D T Bonthron
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James’s University Hospital, Leeds LS9 7TF, UK;

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We refer to the recent paper by Durno et al “Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma” (Gut 2005;54:1146–50).

Among other patients with early onset colorectal cancer (CRC), the authors discuss a girl with CRC onset at the age of 12 years, and a subsequent second primary tumour (glioblastoma). This patient appears to be the sister of a male Turcot syndrome patient described …

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  • Conflict of interest: None declared.

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