Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in ApcMin/+ mice

T Aparicio; L Kotelevets; A Tsocas; J-P Laigneau; I Sobhani; E Chastre; T Lehy

doi:10.1136/gut.2004.060533

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Colon cancer

Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc^Min/+ mice

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	Abstract	Full	Pdf
Apr 2005	10	0	15
May 2005	22	0	122
Jun 2005	16	0	36
Jul 2005	50	57	75
Aug 2005	34	98	62
Sep 2005	18	69	26
Oct 2005	22	69	18
Nov 2005	24	35	11
Dec 2005	19	46	14
Jan 2006	16	18	13
Feb 2006	9	17	19
Mar 2006	1	17	15
Apr 2006	10	20	29
May 2006	7	16	10
Jun 2006	5	19	7
Jul 2006	13	14	8
Aug 2006	7	34	35
Sep 2006	7	30	25
Oct 2006	12	56	43
Nov 2006	11	28	23
Dec 2006	5	43	24
Jan 2007	11	37	28
Feb 2007	5	35	17
Mar 2007	14	56	29
Apr 2007	17	9	9
May 2007	13	17	13
Jun 2007	16	21	17
Jul 2007	15	30	19
Aug 2007	12	11	11
Sep 2007	13	10	14
Oct 2007	14	18	15
Nov 2007	8	24	20
Dec 2007	11	12	14
Jan 2008	12	12	13
Feb 2008	25	17	11
Mar 2008	52	9	8
Apr 2008	37	16	14
May 2008	15	4	5
Jun 2008	5	3	2
Jul 2008	27	24	11
Aug 2008	24	11	10
Sep 2008	43	4	9
Oct 2008	36	6	10
Nov 2008	77	8	7
Dec 2008	23	14	17
Jan 2009	20	13	12
Feb 2009	16	2	10
Mar 2009	24	2	2
Apr 2009	26	5	10
May 2009	12	7	5
Jun 2009	22	5	11
Jul 2009	20	1	2
Aug 2009	18	1	3
Sep 2009	12	6	9
Oct 2009	52	5	6
Nov 2009	26	5	5
Dec 2009	70	4	4
Jan 2010	29	1	4
Feb 2010	27	8	11
Mar 2010	20	5	9
Apr 2010	15	7	7
May 2010	46	1	3
Jun 2010	31	3	6
Jul 2010	46	5	5
Aug 2010	75	13	16
Sep 2010	48	13	2
Oct 2010	47	10	5
Nov 2010	22	15	11
Dec 2010	24	15	4
Jan 2011	39	25	10
Feb 2011	18	12	5
Mar 2011	70	21	11
Apr 2011	20	5	6
May 2011	25	2	2
Jun 2011	12	2	4
Jul 2011	21	7	2
Aug 2011	11	12	3
Sep 2011	19	3	6
Oct 2011	22	3	4
Nov 2011	37	11	8
Dec 2011	16	25	14
Jan 2012	20	18	19
Feb 2012	27	27	6
Mar 2012	18	32	14
Apr 2012	36	23	18
May 2012	21	41	9
Jun 2012	20	22	24
Jul 2012	17	13	11
Aug 2012	20	19	12
Sep 2012	14	19	21
Oct 2012	16	10	19
Nov 2012	22	8	13
Dec 2012	23	5	15
Jan 2013	15	10	10
Feb 2013	29	12	15
Mar 2013	23	12	23
Apr 2013	23	5	15
May 2013	11	6	21
Jun 2013	7	5	14
Jul 2013	10	4	11
Aug 2013	8	7	23
Sep 2013	17	7	19
Oct 2013	23	24	22
Nov 2013	9	6	18
Dec 2013	13	19	29
Jan 2014	18	2	19
Feb 2014	23	1	27
Mar 2014	15	7	51
Apr 2014	19	6	41
May 2014	15	4	20
Jun 2014	9	3	11
Jul 2014	26	20	21
Aug 2014	7	26	19
Sep 2014	12	16	8
Oct 2014	11	19	16
Nov 2014	14	27	6
Dec 2014	12	16	10
Jan 2015	17	14	7
Feb 2015	11	6	11
Mar 2015	18	14	12
Apr 2015	15	6	12
May 2015	14	5	7
Jun 2015	13	3	19
Jul 2015	8	3	10
Aug 2015	6	7	4
Sep 2015	34	6	11
Oct 2015	8	0	4
Nov 2015	13	5	10
Dec 2015	38	6	5
Jan 2016	21	4	7
Feb 2016	13	8	15
Mar 2016	19	1	7
Apr 2016	12	4	8
May 2016	17	9	4
Jun 2016	10	9	4
Jul 2016	14	5	3
Aug 2016	11	14	5
Sep 2016	26	2	17
Oct 2016	33	7	12
Nov 2016	31	10	4
Dec 2016	19	8	2
Jan 2017	24	8	3
Feb 2017	20	9	6
Mar 2017	5	13	1
Apr 2017	5	39	2
May 2017	4	24	4
Jun 2017	5	15	9
Jul 2017	21	17	5
Aug 2017	21	18	11
Sep 2017	24	22	6
Oct 2017	34	32	7
Nov 2017	31	21	5
Dec 2017	14	14	2
Jan 2018	19	17	6
Feb 2018	30	28	11
Mar 2018	19	15	6
Apr 2018	43	39	13
May 2018	34	34	55
Jun 2018	22	22	23
Jul 2018	24	18	28
Aug 2018	12	12	42
Sep 2018	22	18	28
Oct 2018	19	13	54
Nov 2018	28	24	78
Dec 2018	24	18	53
Jan 2019	18	16	30
Feb 2019	26	20	36
Mar 2019	26	24	36
Apr 2019	18	17	29
May 2019	26	25	28
Jun 2019	21	13	31
Jul 2019	42	30	38
Aug 2019	7	7	33
Sep 2019	8	8	45
Oct 2019	24	18	53
Nov 2019	17	15	41
Dec 2019	28	23	67
Jan 2020	12	12	48
Feb 2020	16	14	43
Mar 2020	7	5	51
Apr 2020	9	5	61
May 2020	15	12	18
Jun 2020	22	20	16
Jul 2020	34	32	18
Aug 2020	38	33	24
Sep 2020	56	52	29
Oct 2020	55	51	76
Nov 2020	55	49	75
Dec 2020	55	51	52
Jan 2021	26	21	19
Feb 2021	12	12	7
Mar 2021	28	20	14
Apr 2021	21	13	6
May 2021	19	17	12
Jun 2021	8	8	6
Jul 2021	16	15	20
Aug 2021	13	12	10
Sep 2021	23	23	7
Oct 2021	30	18	29
Nov 2021	32	24	22
Dec 2021	13	11	4
Jan 2022	26	17	2
Feb 2022	22	23	3
Mar 2022	31	30	13
Apr 2022	21	19	10
May 2022	31	24	11
Jun 2022	52	31	12
Jul 2022	28	21	6
Aug 2022	27	20	10
Sep 2022	38	31	14
Oct 2022	26	23	19
Nov 2022	32	28	12
Dec 2022	23	15	6
Jan 2023	24	20	5
Feb 2023	37	35	6
Mar 2023	15	11	10
Apr 2023	8	5	7
May 2023	9	6	7
Jun 2023	8	2	1
Jul 2023	17	8	11
Aug 2023	11	9	6
Sep 2023	40	36	2
Oct 2023	125	125	6
Nov 2023	312	308	7
Dec 2023	144	13	3
Jan 2024	55	0	1
Feb 2024	102	1	9
Mar 2024	98	3	1
Total	5687	4131	3832

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