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HCV genotype 2 as a risk factor for reactivation of chronic HCV infection
  1. N Coppola,
  2. L M Vatiero,
  3. E Sagnelli
  1. Division of Infectious Diseases, San Sebastiano Hospital, Caserta, Italy, and Department of Public Medicine, Section of Infectious Diseases, 2nd University of Naples, Naples, Italy
  1. Correspondence to:
    Professor E Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, c/o Ospedale Gesù e Maria, via D Cotugno 1, 80135, Naples, Italy;

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Little information is available in the literature on acute exacerbation of chronic hepatitis C (r-CHC).1–5 In Taiwan, Sheen et al estimated an annual incidence rate of 11.9%.3 In this study, 40.2% of 78 patients experienced at least one episode of reactivation during a mean observation period of six years and a total of 151 episodes of reactivation were observed, 45% of them symptomatic. The paper by Rumi et al from Milan (Gut 2005;54:402–6) on r-CHC in relation to hepatitis C virus (HCV) genotyping described it as frequent in patients with genotype 2c (39% of 100 patients) and infrequent in those with genotype 1b (7.5% of 106 patients), with a rate×1000 persons/year of 55.6 and 15.0, respectively. From January 2002 to the …

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  • Conflict of interest: None declared.

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