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Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect
  1. N M Neary,
  2. M R Druce,
  3. C J Small,
  4. S R Bloom
  1. Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, UK
  1. Correspondence to:
    Professor S Bloom
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, 6th Floor Commonwealth Building, Du Cane Rd, London W12 ONN, UK; s.bloom{at}imperial.ac.uk

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    We were interested to read the article of Asakawa et al (Gut 2005;54:18–24) which reported that intracerebroventricular and peripheral administration of desacylated ghrelin inhibited food intake in mice in the fasted state. Acylated ghrelin (AG) has a unique biological structure with an acyl side chain on the third amino acid residue. AG is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a)1 and stimulates feeding and growth hormone release. In contrast, desacylated ghrelin (DAG), which does not have the acyl side chain, has no affinity for the GHS-R1a.1 As the authors …

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    • Conflict of interest: None declared.

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