Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation

O M Sieber; S Segditsas; A L Knudsen; J Zhang; J Luz; A J Rowan; S L Spain; C Thirlwell; K M Howarth; E E M Jaeger; J Robinson; E Volikos; A Silver; G Kelly; S Aretz; I Frayling; P Hutter; M Dunlop; T Guenther; K Neale; R Phillips; K Heinimann; I P M Tomlinson

doi:10.1136/gut.2005.087106

Article info

Colorectal cancer

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation

Authors

O M Sieber Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
S Segditsas Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
A L Knudsen The Danish Polyposis Register, Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark PubMed articles Google scholar articles
J Zhang Research Group Human Genetics, Department of Research DKBW, University of Basel, Basel, Switzerland PubMed articles Google scholar articles
J Luz Research Group Human Genetics, Department of Research DKBW, University of Basel, Basel, Switzerland PubMed articles Google scholar articles
A J Rowan Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
S L Spain Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
C Thirlwell Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
K M Howarth Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
E E M Jaeger Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
J Robinson Colorectal Cancer Unit, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
E Volikos Colorectal Cancer Unit, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
A Silver Colorectal Cancer Unit, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
G Kelly Computational Genome Analysis Laboratory, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
S Aretz Institute of Human Genetics, University of Bonn, Wilhelmstrasse, Bonn, Germany PubMed articles Google scholar articles
I Frayling Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK PubMed articles Google scholar articles
P Hutter Institut Central des Hôpitaux Valaisans, Sion, Switzerland PubMed articles Google scholar articles
M Dunlop Colon Cancer Genetics Group, MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK PubMed articles Google scholar articles
T Guenther Academic Department of Histopatholgy, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles
K Neale Polyposis Registry, Cancer Research UK, St Mark’s Hospital, Harrow, UK PubMed articles Google scholar articles
R Phillips Polyposis Registry, Cancer Research UK, St Mark’s Hospital, Harrow, UK PubMed articles Google scholar articles
K Heinimann Research Group Human Genetics, Department of Research DKBW, University of Basel, Basel, Switzerland PubMed articles Google scholar articles
I P M Tomlinson Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK, and Colorectal Cancer Unit, Cancer Research UK, London Research Institute, London, UK PubMed articles Google scholar articles

Correspondence to:
Dr I Tomlinson
Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK; ian.tomlinson{at}cancer.org.uk

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Citation

Sieber OM, Segditsas S, Knudsen AL, et al

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation

Gut 2006;55:1440-1448.

Publication history

Revised January 18, 2006
Accepted January 21, 2006
First published February 4, 2006.

Online issue publication

January 09, 2022

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