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Genetic risk factors are attributed an important role in the pathogenesis of chronic pancreatitis.1 The genetic basis of chronic pancreatitis is complex. The cationic trypsinogen gene,2 serine protease inhibitor Kazal type 1 (SPINK1),3 and cystic fibrosis transmembrane conductance regulator4 genes have been most extensively studied in chronic pancreatitis. However, the frequency of hereditary pancreatitis, which may be related to the trypsinogen gene and SPINK1 in Orientals, is regarded as relatively low and hardly explains the genetic susceptibility of chronic pancreatitis in Chinese.5 Chronic pancreatitis is a progressive chronic inflammatory disease characterised by irreversible destruction of exocrine pancreatic tissue and extensive fibrosis. Tumour necrosis factor (TNF)-α, a prototype proinflammatory cytokine, has been implicated as an important pathogenic mediator in a variety of inflammatory diseases. …
Conflict of interest: None declared.