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  • CARD15 allele frequency differences in New Zealand Maori: ancestry specific susceptibility to Crohn’s disease in New Zealand?

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Letter
CARD15 allele frequency differences in New Zealand Maori: ancestry specific susceptibility to Crohn’s disease in New Zealand?
  1. R B Gearry1,
  2. R A Lea2,
  3. R L Roberts3,
  4. G K Chambers4,
  5. M L Barclay5,
  6. M A Kennedy6
  1. 1Department of Gastroenterology, Christchurch Hospital, and Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
  2. 2Population and Environmental Health Group, Institute of Environmental Science and Research, Christchurch, New Zealand
  3. 3Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
  4. 4School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
  5. 5Department of Gastroenterology, Christchurch Hospital, and Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
  6. 6Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
  1. Correspondence to:
    Dr M L Barclay
    Department of Gastroenterology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand; murray.barclay{at}cdhb.govt.nz

http://dx.doi.org/10.1136/gut.2005.085464

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    The discovery in 2001 that three single nucleotide polymorphisms (SNPs) in the CARD15 gene are associated with Crohn’s disease is one of the most important advances in inflammatory bowel disease (IBD) research in recent years.1,2 This finding has led to further insights into disease pathogenesis,3 and subsequent genotype-phenotype studies have suggested that these SNPs are associated with an increased risk of terminal ileal and complicated disease behaviour.4 Interestingly, alleles of these CARD15 SNPs are known to vary significantly among ethnic subgroups,5 which may have important implications for the ethnic specific risk of Crohn’s disease. In this letter, we report CARD15 allele frequencies for the New Zealand (NZ) Maori population and discuss these …

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    Footnotes

    • RG is the recipient of the CMRF Fellowship. RR is the recipient of a FRST postdoctoral fellowship.

    • Conflict of interest: None declared.