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As a new exciting non-invasive diagnostic technology, wireless capsule endoscopy (WCE) has demonstrated its power in examining the small bowel. There is growing acceptance globally not only in the investigation of obscure gastrointestinal bleeding, but in several uncommon diseases such as Behcet’s disease,1 Whipple’s disease,2 even hereditary polyposis syndromes, and so on. In 2005, several articles in Gut discussed its increasing role in the diagnosis of Crohn’s disease.3–5
Cronkhite-Canada syndrome (CCS) is a rare non-hereditary gastrointestinal polyposis with ectodermal changes, first reported in 1955. Intestinal polyposis is one of the common features but there are few published studies showing the direct view in vivo, which has been confirmed mainly by radiological studies previously, partly because of the limitations of the technique. Hence WCE was performed to learn more about the small bowel mucosa in CCS.