Article Text

Download PDFPDF
Neoadjuvant chemoradiation treatment impairs accuracy of MRI staging in rectal carcinoma
  1. J Jonas,
  2. R Bähr
  1. Department of General, Visceral and Thoracic Surgery, Municipal Hospital Karlsruhe, Karlsruhe, Germany
  1. Correspondence to:
    Dr J Jonas
    Department of General, Visceral and Thoracic Surgery, Municipal Hospital Karlsruhe, Moltkestr 90, 76133 Karlsruhe, Germany; joerg.jonas{at}klinikum-karlsruhe.com

Statistics from Altmetric.com

Neoadjuvant chemoradiotherapy (nCRT) is considered one of the treatment modalities of advanced rectal cancer (pT3/T4 or pN+) with the intention of downsizing and downstaging the tumour. Tumour restaging may be useful for planning the operation but tissue alteration after nCRT may disturb the accuracy of the imaging procedures.

Between July 2004 and August 2005, we analysed 28 consecutive patients (18 males, 10 females, ∼63 years) with adenocarcinoma of the middle and distal third of the rectum. High spatial resolution magnet resonance imaging (MRI) with intraluminary contrast and endorectal ultrasonography (EUS) (Olympus EU-M30S, 12 MHz) were performed before and after nCRT as part of their preoperative staging. Radiotherapy was delivered by daily fractions of 1.8 Gy up to a total dose of 50.4 Gy. During days 1–5 and days 29–33 …

View Full Text

Footnotes

  • Conflict of interest: None declared.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.