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Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis
  1. H Sokol1,
  2. P Lepage1,
  3. Ph Seksik2,
  4. J Doré3,
  5. Ph Marteau4
  1. 1INRA, UEPSD, CR de Jouy-en-Josas, Jouy-en-Josas, France
  2. 2Gastroenterology and Nutrition Unit, Hôpital St Antoine, AP-HP, Paris, France
  3. 3INRA, UEPSD, CR de Jouy-en-Josas, Jouy-en-Josas, France
  4. 4Département Médico-chirurgical de Pathologie Digestive, Hôpital Lariboisière, AP-HP, Paris, France
  1. Correspondence to:
    P Seksik
    Hôpital St Antoine, Service de Gastroentérologie, 184 rue du Fg St Antoine, 75012 Paris, France; philippe.seksik{at}sat.aphp.fr

https://doi.org/10.1136/gut.2006.109686

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    Ulcerative colitis is an inflammatory bowel disease (IBD) characterised by a chronic inflammation of the colorectal mucosa. The role of the gut microbiota in triggering or maintenance of the mucosal inflammation is strongly suspected.1 We may postulate that a localised dysbiosis could explain the localisation of the lesions. Many of the recent studies have been made possible by the development of culture-independent techniques, which identify bacteria on the basis of comparisons of the nucleic acid sequence of rRNA molecules. Temporal temperature-gradient gel electrophoresis (TTGE) showed that in healthy people dominant microbiota associated with colonic mucosa is similar from the caecum to the rectum.2 This has also been observed in Crohn’s disease,2 and the dominant microbiota associated with ulcerated mucosa did not differ markedly from the microbiota associated with non-ulcerated mucosa.3

    The aim of this study was to compare the dominant microbiota associated with injured colonic mucosa versus healthy colonic mucosa, using TTGE in patients with active ulcerative colitis.

    Ten patients with active ulcerative colitis were studied, after informed consent was obtained. …

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    Footnotes

    • Competing interests: None.