Article Text

Download PDFPDF

Helicobacter pylori and antibiotic resistance
  1. Francis Megraud
  1. Laboratoire de Bacteriologie, CHU Pellegrin, Bordeaux, France
  1. Dr F Megraud, Laboratoire de Bacteriologie, CHU Pellegrin, 33076 Bordeaux cedex, France; francis.megraud{at}chu-bordeaux.fr

Statistics from Altmetric.com

This is an introduction to the Gut tutorial “Helicobacter pylori and antibiotic resistance” hosted on BMJ Learning—the best available learning website for medical professionals from the BMJ Group.

H pylori is a Gram-negative flagellated spiral bacteria. Infection with H pylori is mainly acquired in childhood. About 15% of infected people will develop a peptic ulcer and 1% will develop gastric cancer during their lifetime. Resistance to antibiotics is important as it leads to treatment failure. The prevalence of H pylori resistance to clarithromycin is <5% for adults in northern Europe, but as high as 20% in southern Europe. Resistance to clarithromycin is caused by previous consumption of macrolides. Resistance is higher in children because prescriptions of these drugs, particularly for children, have increased during the past decade, mainly for respiratory tract infections. The prevalence of H pylori resistance to metronidazole varies from 20–40% in Europe and the USA to 50–80% in developing countries. Metronidazole is used extensively for treating parasitic diseases in tropical countries, which is probably why there is more resistance there. For patients needing a second course of eradication treatment, a regimen should be chosen that does not include antibiotics given previously. Once you successfully eradicate H pylori, adult reinfection rates are low at <1% a year.

To access the tutorial (Interactive Case History), click on BMJ Learning: Take this module on BMJ Learning from the content box at the top right and bottom left of the online article. For more information please go to: http://gut.bmj.com/tutorials/collection.dtl

If prompted, subscribers must sign into Gut with their journal username and password. All users must also complete a one-time registration on BMJ Learning and subsequently log in (with a BMJ Learning username and password) on every visit.

REFERENCES

View Abstract

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.