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We are grateful to Lyra et al for their recently published study showing the apparent safety of bone marrow (BM)-derived mononuclear cell injection for advanced liver cirrhosis.1 We agree that there is an urgent need to develop alternative treatments for liver cirrhosis given the worsening mismatch between the number of patients requiring a liver transplant and the number of organs available for transplantation.
Stem cell therapy has the potential to benefit this group of patients. However, unlike a defined pharmacological treatment there is additional …