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  1. Y N Kallis1,
  2. M R Alison2,
  3. S J Forbes3
  1. 1
    Department of Medicine, St Mary’s Hospital Campus, Imperial College, London, UK
  2. 2
    Institute of Cell and Molecular Science, Queen Mary’s School of Medicine and Dentistry, London, UK
  3. 3
    Tissue Fibrosis and Remodelling Laboratory, MRC/University of Edinburgh Centre for Inflammation Research, Edinburgh, UK
  1. Dr S J Forbes, MRC/University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; stuart.forbes{at}

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We are grateful to Lyra et al for their recently published study showing the apparent safety of bone marrow (BM)-derived mononuclear cell injection for advanced liver cirrhosis.1 We agree that there is an urgent need to develop alternative treatments for liver cirrhosis given the worsening mismatch between the number of patients requiring a liver transplant and the number of organs available for transplantation.

Stem cell therapy has the potential to benefit this group of patients. However, unlike a defined pharmacological treatment there is additional …

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