Statistics from Altmetric.com
The observation of mannan binding lectin (MBL) expression in the small intestine1 suggests that MBL could be a component in the pathogenesis in Crohn’s disease. Seibold et al2 recently compared the frequencies of MBL polymorphisms in 74 patients with Crohn’s disease with 32 healthy controls, and observed a significantly increased frequency of homozygous exon-1 variations. We evaluated the role of MBL polymorphisms, the MBL associated serine protease-2 (MASP-2) and H-ficolin in a cohort of Danish patients with Crohn’s disease.
A total of 171 patients (73 males and 98 females) were evaluated. Age at onset of Crohn’s disease, localisation and disease behaviour were classified according to the Vienna classification.3 Plasma levels of MBL were measured by a functional time resolved immunofluorometric assay.4 Genetic variations in exon-1 …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.