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  • Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn’s disease

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Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn’s disease
  1. R G Nielsen1,
  2. I Vind2,
  3. P Munkholm3,
  4. J C Jensenius4,
  5. S Thiel4,
  6. S Husby5
  1. 1Department of Paediatrics, Odense University Hospital, Denmark
  2. 2Department of Gastroenterology, Hvidovre Hospital, Denmark
  3. 3Department of Gastroenterology, Herlev Hospital, Copenhagen University, Denmark
  4. 4Department of Medical Microbiology and Immunology, Århus University, Denmark
  5. 5Department of Paediatrics, Odense University Hospital, Denmark
  1. Correspondence to:
    Dr Rasmus Gaardskaer Nielsen
    Department of Paediatrics, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark; rgn{at}dadlnet.dk

http://dx.doi.org/10.1136/gut.2006.109504

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    The observation of mannan binding lectin (MBL) expression in the small intestine1 suggests that MBL could be a component in the pathogenesis in Crohn’s disease. Seibold et al2 recently compared the frequencies of MBL polymorphisms in 74 patients with Crohn’s disease with 32 healthy controls, and observed a significantly increased frequency of homozygous exon-1 variations. We evaluated the role of MBL polymorphisms, the MBL associated serine protease-2 (MASP-2) and H-ficolin in a cohort of Danish patients with Crohn’s disease.

    A total of 171 patients (73 males and 98 females) were evaluated. Age at onset of Crohn’s disease, localisation and disease behaviour were classified according to the Vienna classification.3 Plasma levels of MBL were measured by a functional time resolved immunofluorometric assay.4 Genetic variations in exon-1 …

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    Copyright 2007 by Gut