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Patients with functional constipation do not have increased prevalence of colorectal cancer precursors
  1. Annie On On Chan1,
  2. Wai Mo Hui1,
  3. Gigi Leung1,
  4. Teresa Tong1,
  5. Ivan F N Hung1,
  6. Pierre Chan1,
  7. Axel Hsu1,
  8. David But1,
  9. Benjamin C Y Wong1,
  10. Shiu Kum Lam1,
  11. Kwok Fai Lam2
  1. 1Department of Medicine, The University of Hong Kong, Hong Kong
  2. 2Department of Statistics & Actuarial Science, The University of Hong Kong, Hong Kong
  1. Correspondence to:
    Dr A O O Chan
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong; aoochan{at}

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It has always been a controversial subject whether patients with functional constipation have a higher risk of developing colorectal cancer. Watanabe et al1 showed an increase in relative risk (RR) 1.31 of colorectal cancer in those with constipation.1 Roberts et al2 showed an association with >twofold risk of colon cancer (OR 2.36) adjusted for age, race, sex and relevant confounders.2 On the other hand, both studies by Dukas et al3 and Kune et al,4 after adjusting for age, sex and other risk factors showed no increase in risk.

Colorectal cancer develops through the adenoma–carcinoma sequence.5 Thus, we aimed to compare the prevalence of colorectal adenomas in patients with long-standing functional constipation to an age, sex and …

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  • Competing interests: None.