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LONG-TERM EFFECT OF HELICOBACTER PYLORI ERADICATION ON PLASMA HOMOCYSTEINE IN ELDERLY PATIENTS WITH COBALAMIN DEFICIENCY
Cobalamin (B12) deficiency is common in the elderly and this may be associated with hyperhomocysteinaemia, a recognised risk factor for cardiovascular and cerebrovascular diseases. H pylori may be implicated in cobalamin deficiency but the published data are confusing. The authors prospectively evaluated 62 elderly patients with cobalamin deficiency before and after H pylori eradication. They measured homocysteine and cobalamin concentrations before and 6 and 12 months after H pylori eradication. The initial homocysteine mean (SD) levels decreased from 41.0 (27.1) to 21.6 (10.1) mmol/l at the 6 month follow-up (p<0.001) and 13.1 (3.8) mmol/l 12 months after H pylori eradication (p<0.001) (see figure). Conversely, the initial cobalamin mean levels increased from 145.5 (48.7) pmol/l to 209.8 (87.1) pmol/l and to 271.2 (140.8) pmol/l, 6 and 12 months after the treatment, respectively (p<0.001 for both). The data suggest that elderly patients with H pylori and cobalamin deficiency may benefit from eradicating the infection.
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ULCERATIVE COLITIS: NO RISE IN MORTALITY IN A EUROPEAN-WIDE POPULATION-BASED COHORT 10 YEARS AFTER DIAGNOSIS
Estimates of mortality rates associated with ulcerative colitis (UC) are dated and cover populations from limited geographical areas. Höie et al assessed overall mortality in a European cohort of patients with UC, 10 years after diagnosis. This prospective European-wide population-based cohort of patients with UC was recruited from nine centres in seven European countries in 1991–1993. Expected and standardised mortality ratios (SMR) were …
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