Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
In a recent version of Gut, Mainie and colleagues report on patients with persistent symptoms despite acid suppressive therapy.1 This is often presented as a considerable problem and impedance seems useful in the evaluation of these patients. The importance of the phenomenon of proton pump inhibitor(PPI)-refractory symptoms is also stressed in studies in which the need for a new anti-reflux drug is propagated. However, we think some caution is appropriate when speaking of PPI-refractory gastro-oesophageal reflux disease …
Competing interest: None.