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Fibrosis and strictures are common and irreversible complications of Crohn’s disease that potentially necessitate bowel resection. Tranilast, N-(3’,4’-dimethoxycinnamoyl) anthranilic acid, inhibits keloid scar formation through the inhibition of production of metalloproteinases and tissue inhibitor of metalloproteinase-1 from neutrophils.1 Please check the phrase “inhibition of … neutrophils” is OK Tranilast has been shown to inhibit fibrosis in various experimental models.2–4 Randomised, double-blind, placebo-controlled studies have shown substantial inhibition by tranilast of restenosis of coronary arteries.5–7 A case report has demonstrated the efficacy of long-term administration of tranilast in inflammatory endobronchial stenosis.8
Between June 2001 and July 2005, 24 patients with quiescent Crohn’s disease with non-symptomatic intestinal strictures were recruited. Baseline intestinal stricture was evaluated by small bowel barium enteroclysis, or …
Competing interests: None declared.
This study was approved by the ethical committee of Osaka City University and informed consent was obtained from all the patients.
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