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Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study
  1. Jukka Ronkainen1,
  2. Nicholas J Talley2,
  3. Pertti Aro1,
  4. Tom Storskrubb1,
  5. Sven-Erik Johansson1,
  6. Tore Lind3,
  7. Elisabeth Bolling-Sternevald1,
  8. Michael Vieth4,
  9. Manfred Stolte4,
  10. Marjorie M Walker5,
  11. Lars Agréus1
  1. 1Department of Neurobiology, Care Sciences and Society, Centre for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden
  2. 2Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, USA
  3. 3Astra Zeneca R&D, Mölndal, Sweden
  4. 4Institute of Pathology, Bayreuth, Germany
  5. 5Department of Histopathology, Faculty of Medicine, Imperial College, London, UK
  1. Correspondence to:
    Dr Ronkainen (CeFAM
    Karolinska Institutet) Ylipurrantie 17, SF-95410, Finland; jukka.ronkainen{at}


Background: Eosinophilic oesophagitis may be increasing but the prevalence in the general population remains unknown. Our aim was to assess this and the presence of eosinophils in the distal oesophageal epithelium in the community.

Methods: Oesophagogastroduodenoscopy was performed in a random sample (n = 1000) of the adult Swedish population (mean age 54 years, 49% men). Oesophageal biopsy samples were obtained from 2 cm above, and at, the Z-line. Any eosinophil infiltration of the epithelium was defined as “eosinophils present”. Definite eosinophilic oesophagitis was defined as ⩾20, probable as 15–19, and possible as 5–14 eosinophils/high-power field (HPF, at magnification ×40) in oesophageal biopsy specimens.

Results: Eosinophils were present in 48 subjects (4.8%, 95% CI 3.5 to 6.1%, mean age 54 years, 63% men), in 54% without troublesome reflux symptoms. Definite eosinophilic oesophagitis was present in four subjects (0.4%, 95% CI 0.01 to 0.8%, mean age 51 years, 75% men) and probable eosinophilic oesophagitis in seven subjects (0.7%, 95% CI 0.2 to 1.2%, mean age 58 years, 43% men). Erosive oesophagitis (OR = 2.99, 95% CI 1.58 to 5.66) and absence of dyspepsia (OR = 0.23, 95% CI 0.07 to 0.75) and Helicobacter pylori infection (OR = 0.41, 95% CI 0.19 to 0.92) were independent predictors for “eosinophils present”. Definite eosinophilic oesophagitis was associated with dysphagia (2/66 vs 2/926, p = 0.025), and probable eosinophilic oesophagitis with narrowing of the oesophageal lumen (2/15 vs 5/978, p = 0.005).

Conclusions: Oesophageal eosinophils were present in nearly 5% of the general population; approximately 1% had definite or probable eosinophilic oesophagitis. Oesophageal eosinophils may be a manifestation of reflux disease in adults, but the condition is as likely to be asymptomatic and go unrecognised.

  • ASQ, Abdominal Symptom Questionnaire
  • GORD, gastro-oesophageal reflux disease
  • HPF, high-power field
  • eosinophilic oesophagitis
  • epidemiology
  • gastro-oesophageal reflux disease
  • population-based

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  • Published Online First 27 November 2006

  • Competing interests: None.

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