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We write in response to the article by Swallow (Gut 2006;55:131) in which a DNA test was considered premature for diagnosing hypolactasia. We would also like to comment on the diagnostic conclusions of Ransinpera et al1 with regard to younger children.
Recently, the C/T-13910 polymorphism on chromosome 2q21 in Northern European populations has been found to be completely associated with lactase activity2 and proposed as a new diagnostic tool in adult-type hypolactasia.1 Although in some African groups other polymorphisms can be present (Swallow et al), the same polymorphism has also been found in non-Northern European populations.3–5
The lactose breath …
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