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Genetic testing is ready to change the diagnostic scenario of lactose malabsorption
  1. P Usai Satta1,
  2. M Congia2,
  3. E Schirru2,
  4. M Scarpa1,
  5. G Mura1
  1. 1
    Gastroenterology Unit, Brotzu Hospital, Piazza Ricchi 1, 09121 Cagliari, Italy
  2. 2
    Department of Biomedical Science and Biotechnology, University of Cagliari, Via Jenner, 09121 Cagliari, Italy
  1. Dr P Usai Satta, Gastroenterology Unit, Brotzu Hospital, Piazza Ricchi 1, 09121 Cagliari, Italy; paolousai{at}

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We write in response to the article by Swallow (Gut 2006;55:131) in which a DNA test was considered premature for diagnosing hypolactasia. We would also like to comment on the diagnostic conclusions of Ransinpera et al1 with regard to younger children.

Recently, the C/T-13910 polymorphism on chromosome 2q21 in Northern European populations has been found to be completely associated with lactase activity2 and proposed as a new diagnostic tool in adult-type hypolactasia.1 Although in some African groups other polymorphisms can be present (Swallow et al), the same polymorphism has also been found in non-Northern European populations.35

The lactose breath …

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