Article Text

Download PDFPDF
Predicting relapse in Crohn’s disease: a biopsychosocial model
  1. A Bitton1,
  2. P L Dobkin1,
  3. M D Edwardes1,
  4. M J Sewitch1,
  5. J B Meddings2,
  6. S Rawal1,
  7. A Cohen3,
  8. S Vermeire4,
  9. L Dufresne1,
  10. D Franchimont1,
  11. G E Wild1,5
  1. 1
    McGill University Health Centre, Montreal, Canada
  2. 2
    University of Alberta, Canada
  3. 3
    Jewish General Hospital, Montreal, Canada
  4. 4
    University Hospital Gasthuisberg, Leuven, Belgium
  5. 5
    Douglas Hospital Center for Studies on Human Stress, Montreal, Canada
  1. Dr A Bitton, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A1; alain.bitton{at}


Background: Crohn’s disease (CD) is a chronic relapsing inflammatory bowel disorder. Both biological and psychosocial factors may modulate the illness experience.

Aim: The aim of this study was to identify clinical, biological and psychosocial parameters as predictors of clinical relapse in quiescent CD.

Methods: Patients in medically induced remission were followed prospectively for 1 year, or less if they relapsed. Disease characteristics were determined at baseline. Serum cytokines, anti-Saccharomyces cerevisiae antibodies, C-reactive protein (CRP), erythrocyte sedimentation rate and intestinal permeability were measured every 3 months. Psychological distress, perceived stress, minor life stressors and coping strategies were measured monthly. A time-dependent multivariate Cox regression model determined predictors of time to relapse.

Results: 101 patients (60 females, 41 males) were recruited. Fourteen withdrew and 37 relapsed. CRP (HR = 1.5 per 10 mg/l, 95% CI 1.1 to 1.9, p = 0.007), fistulising disease (HR = 3.2, 95% CI, 1.1 to 9.4, p = 0.04), colitis (HR = 3.5 95% CI 1.2 to 9.9, p = 0.02) and the interaction between perceived stress and avoidance coping (HR = 7.0 per 5 unit increase for both scales, 95% CI 2.3 to 21.8, p = 0.003) were predictors of earlier relapse.

Conclusions: In quiescent CD, a higher CRP, fistulising disease behaviour and disease confined to the colon were independent predictors of relapse. Moreover, patients under conditions of low stress and who scored low on avoidance coping (ie, did not engage in social diversion or distraction) were least likely to relapse. This study supports a biopsychosocial model of CD exacerbation.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • See Commentary, p 1345

  • Funding: Supported by a research grant from the Crohn’s and Colitis Foundation of Canada.

  • Competing interests: None.

  • Ethics approval: The protocol was approved by the Institutional Review Boards of the participating hospitals.

  • Patient consent: Obtained.

Linked Articles