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We were most interested to read the recent report by Serviddio and colleagues (Gut 2008;57:957–65). This work not only showed that upregulation of uncoupling protein-2 was a reason for progression of non-alcoholic steatohepatitis (NASH) from simple steatosis, but also gave an explanation for why NASH liver was especially vulnerable to ischaemia–reperfusion injury.
NASH is a common liver disease that is estimated to affect nearly 1% of the population. A growing body of evidences shows that NASH …
Competing interests: None.
Ethics approval: Ethics approval for the animal study was given by The Ethical Committee of the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, 15 January 2006.
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