Article Text

Download PDFPDF
Decreased number of activated macrophages in gallbladder muscle layer of cholesterol gallstone patients following ursodeoxycholic acid
  1. M P L Guarino1,
  2. S Carotti2,
  3. S Morini2,
  4. G Perrone3,
  5. J Behar4,
  6. A Altomare1,
  7. R Alloni1,
  8. R Caviglia1,
  9. S Emerenziani1,
  10. C Rabitti3,
  11. M Cicala1
  1. 1
    Department of Digestive Diseases, Campus Bio-Medico University, Rome, Italy
  2. 2
    Department of Biomedical Research, Campus Bio-Medico University, Rome, Italy
  3. 3
    Surgical Pathology, Campus Bio-Medico University, Rome, Italy
  4. 4
    Rhode Island Hospital and Brown University Medical School, Providence, Rhode Island, USA
  1. Dr M P L Guarino, Dipartimento di Malattie dell’Apparato Digerente, Università Campus Bio-Medico, Via Alvaro del Portillo, 21–00128 Rome, Italy; m.guarino{at}

Statistics from

We recently reported that, in symptomatic cholesterol gallstone patients, ursodeoxycholic acid (UDCA) improves gallbladder (GB) muscle contractility and decreases the biochemical parameters of oxidative stress and inflammation.1 UDCA also antagonises the hydrophobic bile acid damage to the liver by preventing hydrophobic bile acid-induced stimulation of macrophage oxidative processes.2 3 Macrophages also play a dominant role in the inflammatory and oxidative response in other conditions associated with impairment of intestinal motility, such as post-operative ileus.46 Following these findings, we carried out additional studies aimed at examining: the presence of macrophage infiltration and cyclooxygenase-2 (COX-2) expression in the GB muscle layer and the effect of short-term UDCA administration.

From February 2004 to August 2007, …

View Full Text


  • Competing interests: None.

  • Ethics approval: This study was approved by the Ethics Committee of Campus Bio-Medico University on 21 June 2001.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.