R Spiller, Q Aziz, F Creed, et al. Guidelines on the irritable bowel syndrome: mechanisms and practical management (Gut 2007;56:1770–98). In paragraph 4.4.1 the sentence “This in turn acts on the adrenal medulla, resulting in cortisol secretion into the circulation” should read “This in turn acts on the adrenal cortex, resulting in cortisol secretion into the circulation”.