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We read with interest the letter by Mañosa and colleagues and thank the editors of Gut for the opportunity to provide a brief response.
Drug-induced lupus erythematosus (DILE) is a rare disorder infrequently observed during the treatment of patients with all current anti-tumour necrosis factor (TNF) therapies for a variety of autoimmune diseases, including Crohn’s disease. In a published overview of the safety of adalimumab in the treatment of rheumatoid arthritis, for example, 13 cases of “lupus-like syndrome” were reported during 12 406 patient-years of drug exposure.1 In the comprehensive adalimumab clinical development programme for Crohn’s disease, investigators ascertained three cases of lupus or lupus-like syndrome with 1506 patient-years of exposure.2 Of …
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