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Author’s reply
  1. William J Sanborn,
  2. on behalf of the CLASSIC-II study authors
  1. Mayo Clinic, Rochester, Minnesota, USA
  1. Dr William J Sandborn, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55902, USA; sandborn.william{at}mayo.edu

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We read with interest the letter by Mañosa and colleagues and thank the editors of Gut for the opportunity to provide a brief response.

Drug-induced lupus erythematosus (DILE) is a rare disorder infrequently observed during the treatment of patients with all current anti-tumour necrosis factor (TNF) therapies for a variety of autoimmune diseases, including Crohn’s disease. In a published overview of the safety of adalimumab in the treatment of rheumatoid arthritis, for example, 13 cases of “lupus-like syndrome” were reported during 12 406 patient-years of drug exposure.1 In the comprehensive adalimumab clinical development programme for Crohn’s disease, investigators ascertained three cases of lupus or lupus-like syndrome with 1506 patient-years of exposure.2 Of …

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Footnotes

  • Funding: WS has received research support from and has served as a consultant for Abbott Laboratories, Centocor, Schering Plough and UCB Pharma, and has participated in continuing medical education events indirectly sponsored by Abbott Laboratories, Centocor, Schering Plough and UCB Pharma.

  • Competing interests: Declared (the declaration can be viewed on the Gut website at http://gut.bmj.com/content/vol57/issue4).

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