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We read with interest the letter by Mañosa and colleagues and thank the editors of Gut for the opportunity to provide a brief response.
Drug-induced lupus erythematosus (DILE) is a rare disorder infrequently observed during the treatment of patients with all current anti-tumour necrosis factor (TNF) therapies for a variety of autoimmune diseases, including Crohn’s disease. In a published overview of the safety of adalimumab in the treatment of rheumatoid arthritis, for example, 13 cases of “lupus-like syndrome” were reported during 12 406 patient-years of drug exposure.1 In the comprehensive adalimumab clinical development programme for Crohn’s disease, investigators ascertained three cases of lupus or lupus-like syndrome with 1506 patient-years of exposure.2 Of …
Funding: WS has received research support from and has served as a consultant for Abbott Laboratories, Centocor, Schering Plough and UCB Pharma, and has participated in continuing medical education events indirectly sponsored by Abbott Laboratories, Centocor, Schering Plough and UCB Pharma.
Competing interests: Declared (the declaration can be viewed on the Gut website at http://gut.bmj.com/content/vol57/issue4).
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