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Both gluten-sensitive enteropathy (GSE) and inflammatory bowel diseases (IBDs) are characterised by inflammation of the intestinal mucosa and enhanced intestinal epithelial permeability. Previous studies have identified shared susceptibility genes for IBD and GSE. Myosin IXB, first identified as associated with GSE, was also proven to be associated with ulcerative colitis (UC).1 We would like to respond to the recent study performed by Wapenaar et al that identified two tight-junction genes, PARD3 and MAGI2, to be associated with both GSE and UC (Gut 2008;57:438). We have also found IBD-associated genetic variants in DLG5 to be associated with GSE.2 DLG5 is, like Myosin IXB, PARD3 and MAGI2, involved in maintaining the epithelial integrity, which makes it a suitable candidate gene for …
Competing interests: None.
Ethics approval: The study was approved by the ethics committees of the hospitals in Utrecht and Groningen.
Patient consent: Written informed consent was obtained from all subjects.
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