Statistics from Altmetric.com
Peterson et al report their follow-up of a number of signals identified in recent genome-wide association (GWA) scans in Crohn’s disease. In addition to their relevance to paediatric Crohn’s disease, which to date appears similar to adult disease at a genetic level, their findings also illustrate a number of points relevant to the interpretation of case–control genetic association studies in general. It is worth detailing these, as a number of investigators find themselves with an irritable bowel disease (IBD) DNA resource and wondering about its utility as a replication set.
Although for a paediatric panel the data set used by Peterson et al is commendably sizeable, nonetheless in the context of the known effect sizes of the loci they were …
Competing interests: None.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.