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In their letter, Robaeys et al refer to our study1 on the antidepressant treatment of interferon (IFN)-induced depression in patients with chronic hepatitis C virus (HCV) infection.
We fully agree with the authors’ statements that (1) prescription of a selective serotonin reuptake inhibitor (SSRI) is indicated and highly effective1 when clinically relevant symptoms of depression emerge and (2) the exact mechanisms by which SSRIs reduce depression in these patients are still unclear. Nevertheless, with respect to the latter point, …