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Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn’s disease
  1. D Roggenbuck1,
  2. G Hausdorf2,
  3. L Martinez-Gamboa2,
  4. D Reinhold3,
  5. T Büttner1,
  6. P R Jungblut4,
  7. T Porstmann5,
  8. M W Laass6,
  9. J Henker6,
  10. C Büning7,
  11. E Feist2,
  12. K Conrad8
  1. 1
    GA Generic Assays GmbH, Dahlewitz, Germany
  2. 2
    Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany
  3. 3
    Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
  4. 4
    Max Planck Institute for Infection Biology, Berlin, Germany
  5. 5
    Seramun Diagnostica GmbH, Heidesee, Germany
  6. 6
    Clinic of Pediatrics, Technical University Dresden, Dresden, Germany
  7. 7
    Department of Gastroenterology, Hepatology, and Endocrinology, Charité Universitätsmedizin Berlin, Berlin, Germany
  8. 8
    Institute of Immunology, Technical University Dresden, Dresden, Germany
  1. Correspondence to Dr K Conrad, Institute of Immunology, Technical University Dresden, Fetscherstraße 74, 01307 Dresden, Germany; k_conrad{at}mail.zih.tu-dresden.de

Footnotes

  • Funding This work was supported by the Brandenburg Ministry of Economics and European Union grant 80130073.

  • Competing interests DR is a shareholder of GA Generic Assays GmbH. TP is a shareholder of both Seramun Diagnostica GmbH and GA Generic Assays GmbH. Both companies are diagnostic manufacturers. The remaining authors have no competing interests.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Ethics approval This study was approved by the local ethics committee of the Medical Faculty, Technical University Dresden, on 3 May 2007. The animals used in this study were handled according to German regulations concerning the protection of animals.

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Footnotes

  • Funding This work was supported by the Brandenburg Ministry of Economics and European Union grant 80130073.

  • Competing interests DR is a shareholder of GA Generic Assays GmbH. TP is a shareholder of both Seramun Diagnostica GmbH and GA Generic Assays GmbH. Both companies are diagnostic manufacturers. The remaining authors have no competing interests.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Ethics approval This study was approved by the local ethics committee of the Medical Faculty, Technical University Dresden, on 3 May 2007. The animals used in this study were handled according to German regulations concerning the protection of animals.

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