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Germline variants of IRGM in childhood-onset Crohn’s disease
  1. J Van Limbergen1,2,3,
  2. R K Russell4,
  3. E R Nimmo1,
  4. H E Drummond1,
  5. Davies G1,
  6. D C Wilson2,3,
  7. J Satsangi1
  1. 1
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, UK
  2. 2
    Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh, UK
  3. 3
    Child Life and Health, University of Edinburgh, UK
  4. 4
    Department of Paediatric Gastroenterology, Yorkhill Hospital, Glasgow, UK
  1. Dr J Van Limbergen, Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK; johanvanlimbergen{at}

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Genetic association of the autophagy genes, autophagy-related 16-like 1 (ATG16L1) and immunity-related GTPase family, M (IRGM), has been confirmed by meta-analysis of three index genome-wide association studies (GWASs), and in other independent studies in adult-onset Crohn’s disease, but not ulcerative colitis.15 While the meta-analysis implicated a single nucleotide polymorphism (SNP; rs11747270) based on imputed data from the constituent GWAS with odds ratio (OR) 1.33, other studies have replicated the IRGM signal based on rs13361189 and rs4958847. Recently, rs13361189, upstream of IRGM, was shown to be in perfect linkage disequilibrium with a 20 kb deletion polymorphism affecting the expression of IRGM (and cellular autophagy) in a tissue-specific manner.5

We read with interest the letter by Peterson et al (Gut 2008;57:1336–7) which suggested association of IRGM with childhood-onset Crohn’s disease in a North American cohort. Only one of the two IRGM variants studied (rs13361189) was weakly associated with Crohn’s disease in their study …

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  • Competing interests: None.

  • Funding: JvL is funded by a Research Training Fellowship from Action Medical Research, The Gay–Ramsay–Steel–Maitland or Stafford Trust and the Hazel M Wood Charitable Trust. ERN is supported by a Wellcome Trust Programme Grant (072789/Z/03/Z). Financial assistance was also provided by Schering-Plough and the GI/Nutrition Research Fund, Child Life and Health, University of Edinburgh.

  • Ethics approval: Approval for this study was given by the local research ethics committee on 18 June 2002 and confirmed by the Central Office for Research Ethics Committees (COREC) on 27 January 2006.