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Competing interests: None.
Funding: This work was partially funded by the Spanish Ministry of Education (FPU, AP2002-2696) (to DB), grants from Generalitat Valenciana and CSIC 200570F0091 (to IN), Spanish Ministry of Education (MEC; AGL2005-05788-C02-01), the Spanish Ministry of Health (FIS, I070244) and Phadia Spain, SL.